反应详情

2.3 g of the compound (8) and 1.1 g of potassium hydroxide were dissolved in a solution mixture of 14 ml of water and 6 ml of methanol, and reflux was then carried out for 5 hours. The reaction solution was added into 100 ml of water, and the pH was adjusted approximately to 1 with concentrated hydrochloric acid. The waxen matter generated therein was washed with water and was then dried at 40° C. under reduced pressure, to obtain 2.1 g of the compound (9). (Yield: 93%)

1. temperaturereflux
2. washThe waxen matter generated therein was washed with water
3. customwas then dried at 40° C. under reduced pressure