L-Lysine → L-Leucine, N-((1,1-dimethylethoxy)carbonyl)-

HRID 1755627Notes

Reaction equation

HRID 1755627 reaction equation
[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=CC=C[CH:5]=1.N[C@H]([C:20]([OH:22])=[O:21])CCCCN.N[C@H](C(O)=O)[CH2:25][CH:26]([CH3:28])[CH3:27]>>[NH:1]([C:20]([O:22][C:26]([CH3:28])([CH3:27])[CH3:25])=[O:21])[C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH:4]([CH3:5])[CH3:9]

Participants

4

Reactant 3

HCID 5962L-LysineHCID 6106L-LeucineHCID 6140L-Phenylalanine

Product 1

HCID 83170L-Leucine, N-((1,1-dimethylethoxy)carbonyl)-

Procedure

Yield: 120 mg Rf value: 0.43 (ethyl acetate:butanol:acetic acid: water=1:1:1:1) Amino acid analysis: Asp 1.00; Ser 1.95; Pro 2.06 Val 0.98; Leu 2.01

Sources & evidence

ORD record
ord-7de6f7b73fd54575b022473a22b90ff3
Source dataset
uspto-grants-1995_08
Patent number
US05437995

Reaction notes

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