Acetic Anhydride → HCID 54297980, 화합물

HRID 1755774노트

반응식

HRID 1755774 반응식
[CH:1](=[O:10])[C:2]1[CH:9]=[CH:8][CH:7]=[C:4]([CH:5]=O)[CH:3]=1.[F:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][C:21]=1[F:22])[N:18]=[C:17]([CH3:23])[CH:16]=[CH:15]2.C(OC(=O)C)(=O)C>C1(C)C(C)=CC=CC=1>[F:11][C:12]1[CH:13]=[C:14]2[C:19](=[CH:20][C:21]=1[F:22])[N:18]=[C:17]([CH:23]=[CH:5][C:4]1[CH:3]=[C:2]([CH:9]=[CH:8][CH:7]=1)[CH:1]=[O:10])[CH:16]=[CH:15]2

참가 물질

5

반응물 3

HCID 7918Acetic AnhydrideHCID 34777IsophthalaldehydeHCID 222413776,7-Difluoro-2-methylquinoline

생성물 1

HCID 54297980HCID 54297980, 화합물수율 59,429.102%

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

A solution of isophthalaldehyde (312.4 g, 2.33 mmol), 6,7-difluoro-2-methylquinoline (278.4 g, 1.55 mmol) and acetic anhydride (416 mL) in 2 L of xylene was heated to reflux overnight. The solvent was evaporated and the product was swished in 2.5 L of EtOAc to yield the title compound (272 g, 56%). 1H NMR (CD3COCD3): δ 10.12 (1H, s), 8.4 (1H, d), 8.29 (1H, s), 8.1-7.85 (6H, m), 7.7-7.55 (2H, m).

후처리

  1. temperatureto reflux overnight
  2. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-cd2f3baca05243fa850541135bab93c8
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05438141

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