Methylhydrazine → HCID 178514652, compound

HRID 1755835Notes

Reaction equation

[OH:1][C:2]1[C:3](=[O:21])[N:4]=[C:5]([CH2:8][O:9][N:10]2C(=O)C3=CC=CC=C3C2=O)[NH:6][CH:7]=1.CNN>CN(C)C=O>[NH2:10][O:9][CH2:8][C:5]1[NH:6][CH:7]=[C:2]([OH:1])[C:3](=[O:21])[N:4]=1

Participants

Conditions

Temperature: 10 °C

Procedure

5-Hydroxy-2-[(phthalimidooxy)methyl]-4(1H)-pyrimidinone (0.875 g) (3 mmol) is suspended in 7 ml of dimethylformamide. 136 mg (3 mmol) of methylhydrazine are added thereto at 10° C. and the mixture is stirred at room temperature for 1 hour. The solution is washed four times with 50 ml of n-pentane, the solid residue is taken up in ether, the product is filtered off and crystallized from ethanol. There is obtained 2-(aminooxy)methyl-5-hydroxy-4(1H)-pyrimidinone of m.p. 163° C. (dec.) as white crystals.

Workup

washThe solution is washed four times with 50 ml of n-pentane
filtrationthe product is filtered off
customcrystallized from ethanol

Sources & evidence

ORD record: ord-59af5be550ac4d548ee720e364dcebcb
Source dataset: uspto-grants-1995_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05438052

Reaction notes

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