反应详情

温度

10 °C

5-Hydroxy-2-[(phthalimidooxy)methyl]-4(1H)-pyrimidinone (0.875 g) (3 mmol) is suspended in 7 ml of dimethylformamide. 136 mg (3 mmol) of methylhydrazine are added thereto at 10° C. and the mixture is stirred at room temperature for 1 hour. The solution is washed four times with 50 ml of n-pentane, the solid residue is taken up in ether, the product is filtered off and crystallized from ethanol. There is obtained 2-(aminooxy)methyl-5-hydroxy-4(1H)-pyrimidinone of m.p. 163° C. (dec.) as white crystals.

1. washThe solution is washed four times with 50 ml of n-pentane
2. filtrationthe product is filtered off
3. customcrystallized from ethanol