Hydrogen Bromide → HCID 19917880, compound

HRID 1755857Notes

Reaction equation

HRID 1755857 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([C:11]2[C:12](=[O:17])[NH:13][CH:14]=[N:15][CH:16]=2)[CH:6]=[CH:7][C:8]=1[O:9]C.[BrH:18]>>[BrH:18].[OH:2][C:3]1[CH:4]=[C:5]([C:11]2[C:12](=[O:17])[NH:13][CH:14]=[N:15][CH:16]=2)[CH:6]=[CH:7][C:8]=1[OH:9]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 19917925HCID 19917925, compound

Product 1

HCID 19917880HCID 19917880, compound

Procedure

5-(3,4-Dimethoxyphenyl)-4(3H)-pyrimidinone (9.28 g) (40 mmol) are refluxed in 300 ml of 48% aqueous hydrogen bromide solution for 48 hours. The suspension obtained is suction filtered, the filter material is taken up in water and the product is precipitated by the addition of sodium hydrogen carbonate. The precipitate is filtered off, washed with water and dried at room temperature. There are obtained 8.3 g of 5-(3,4-dihydroxyphenyl)-4(3H)-pyrimidinone hydrobromide as a beige powder. M.p.>270° C.

Workup

  1. customThe suspension obtained
  2. filtrationfiltered
  3. customthe product is precipitated by the addition of sodium hydrogen carbonate
  4. filtrationThe precipitate is filtered off
  5. washwashed with water
  6. customdried at room temperature

Sources & evidence

ORD record
ord-e9055a25a3164baf96dbaced391aea06
Source dataset
uspto-grants-1995_08
Patent number
US05438052

Reaction notes

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