反应详情

3-Amino-5-methyl-1H-s-triazole (112 mg) and 320 mg of dimethyl 2-oxo-succinate are dissolved in 5 ml of glacial acetic acid. After boiling under reflux for 22 hours the solvent is distilled off in a vacuum. The residue is suspended in warm methanol. After cooling the product is filtered off and washed several times with methanol. After drying in a high vacuum there are obtained 73 mg of methyl 7-hydroxy-2-methyl-s-triazolo[1,5-a]pyrimidine-5-carboxylate as a beige powder, m.p.>220° C.

1. temperatureunder reflux for 22 hours the solvent
2. distillationis distilled off in a vacuum
3. temperatureAfter cooling the product
4. filtrationis filtered off
5. washwashed several times with methanol
6. customAfter drying in a high vacuum