HCID 10632456, 화합물 → Oxazole, 5-methyl-2-phenyl-4-(2-propynyl)-

HRID 1755947노트

반응식

HRID 1755947 반응식
[C:1]([NH:9][CH:10]([C:14](=[O:16])[CH3:15])[CH2:11][C:12]#[CH:13])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>FC(F)(F)C(OC(=O)C(F)(F)F)=O.FC(F)(F)C(O)=O>[CH3:15][C:14]1[O:16][C:1]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[N:9][C:10]=1[CH2:11][C:12]#[CH:13]

참가 물질

4

반응물 1

HCID 10632456HCID 10632456, 화합물

생성물 1

HCID 10535929Oxazole, 5-methyl-2-phenyl-4-(2-propynyl)-수율 101.4%

시약·촉매·용매 2

HCID 6422Trifluoroacetic acid용매HCID 9845Trifluoroacetic anhydride용매

실험 절차

A solution of 4-benzoylamino-l-hexyn-5-one (30 g, 0.14 mol) in trifluoroacetic anhydride (100 ml) and trifluoroacetic acid (200 ml) was heated to 35°-40° C. for 6 hours. The solution was concentrated and the residue taken up in ethyl acetate (400 ml). To this solution was added saturated sodium bicarbonate solution (400 ml) followed by solid sodium bicarbonate until the water layer became neutral. The layers were separated, the organic layer was washed with brine, dried over magnesium sulfate and concentrated to give a brown oil (28 g) which was used as such.

후처리

  1. concentrationThe solution was concentrated
  2. additionTo this solution was added saturated sodium bicarbonate solution (400 ml)
  3. customThe layers were separated
  4. washthe organic layer was washed with brine
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-bbe467dd80ff4813becb1dc18e008a11
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05438074

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