Phenethyl bromide → HCID 67780719, compound

HRID 1756042Notes

Reaction equation

HRID 1756042 reaction equation
[CH3:1][C:2]1[NH:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=1.[Br:11][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(#N)C>[BrH:11].[CH3:1][C:2]1[N:10]=[C:5]2[N:6]([CH2:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=1

Participants

4

Reactant 2

HCID 7666Phenethyl bromideHCID 5830662-Methyl-7-azaindole

Product 1

HCID 67780719HCID 67780719, compoundYield 92.6%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 85 mg (0.64 mmol) of 2-methyl-pyrrolo[2,3-b]pyridine and 140 mg(0.76 mmol) of (2-bromoethyl)benzene in 1 ml acetonitrile was refluxed for 40 h. The solvent was evaporated and the residue was treated with ether. The solid that formed was isolated by filtration to give 188 mg (62%) of 2-methyl-7- (2-phenylethyl)pyrrolo[2,3-b]pyridinehydrobromide.

Workup

  1. customThe solvent was evaporated
  2. additionthe residue was treated with ether
  3. customThe solid that formed
  4. customwas isolated by filtration

Sources & evidence

ORD record
ord-f4a8dc231ed4479ab1db8ae1c538cb6f
Source dataset
uspto-grants-1995_08
Patent number
US05439917

Reaction notes

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