Phenethyl bromide → HCID 19916790, compound

HRID 1756046Notes

Reaction equation

HRID 1756046 reaction equation
[OH:1][CH2:2][C:3]1[NH:11][C:6]2=[N:7][CH:8]=[CH:9][CH:10]=[C:5]2[C:4]=1[CH3:12].[Br:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>C(#N)C>[BrH:13].[OH:1][CH2:2][C:3]1[N:11]=[C:6]2[N:7]([CH2:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:8]=[CH:9][CH:10]=[C:5]2[C:4]=1[CH3:12]

Participants

4

Reactant 2

HCID 7666Phenethyl bromideHCID 193926133-Methyl-1H-pyrrolo[2,3-b]pyridine-2-methanol

Product 1

HCID 19916790HCID 19916790, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 0.11 g (0.68 mmol) 2-hydroxymethyl-3-methylpyrrolo [2,3-b]pyridine and 0.13 g (7 mmol) (2-bromoethyl)benzene in 5 ml acetonitril was refluxed for 24 h. The solvent was evaporated. Chromatography on silica gel eluting with methylene chloride and methanol (10:1) gave the desired product. (0.03 g 13%).

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-4c2b772875214f91a2ac770bd11c61d2
Source dataset
uspto-grants-1995_08
Patent number
US05439917

Reaction notes

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