2-Chloroacetophenone → HCID 19916806, compound

HRID 1756053Notes

Reaction equation

HRID 1756053 reaction equation
[CH3:1][C:2]1[NH:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=1.[CH2:11]([Cl:20])[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:13]>C(#N)C>[ClH:20].[CH3:1][C:2]1[N:10]=[C:5]2[N:6]([CH2:11][C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[O:13])[CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=1

Participants

4

Reactant 2

HCID 107572-ChloroacetophenoneHCID 5830662-Methyl-7-azaindole

Product 1

HCID 19916806HCID 19916806, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2-Methyl-pyrrolo[2,3-b]pyridine (0.5 g, 3.78 mmol), phenacyl chloride (0.62 g, 4.0 mmol ) and acetonitrile (10 ml) were refluxed for 12 h. The solid was filtered off and washed with cold carbon tetrachlorid (2 ml). The crude product was recrystallized from chloroform/ether, 1:1, to give 0.95 g (88%) title compound.

Workup

  1. filtrationThe solid was filtered off
  2. washwashed with cold carbon tetrachlorid (2 ml)
  3. customThe crude product was recrystallized from chloroform/ether, 1:1

Sources & evidence

ORD record
ord-0a8f7e8073c3464da875f56b0c3116ec
Source dataset
uspto-grants-1995_08
Patent number
US05439917

Reaction notes

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