2-Chloroacetophenone → HCID 131719075, compound

HRID 1756054Notes

Reaction equation

HRID 1756054 reaction equation
[CH3:1][O:2][C:3]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][CH:10]=2)[NH:5][C:4]=1[CH3:12].[CH2:13]([Cl:22])[C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:15]>C(#N)C>[ClH:22].[CH3:1][O:2][C:3]1[C:11]2[C:6]([N:7]([CH2:13][C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[O:15])[CH:8]=[CH:9][CH:10]=2)=[N:5][C:4]=1[CH3:12]

Participants

4

Reactant 2

HCID 107572-ChloroacetophenoneHCID 199168183-Methoxy-2-methyl-1H-pyrrolo[2,3-b]pyridine

Product 1

HCID 131719075HCID 131719075, compoundYield 34.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 0,75 g (4,6 mmol) 3-methoxy-2-methylpyrrolo[2,3-b]pyridine and 0,75 g (4,8 mmol) phenacyl chloride in 50 ml acetonitrile was refluxed for 14 h. Working up in the same manner as ex. 17 gave 0,5 g (34%) of the desired product.

Sources & evidence

ORD record
ord-093bd02bf22346cca72c635684b1322f
Source dataset
uspto-grants-1995_08
Patent number
US05439917

Reaction notes

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