2-Chloro-3-methyl-7-(p-fluorophenacyl)pyrrolo [2,3-b]pyridine hydrochloride → 2-Chloro-3-methyl-7-(2-(p-fluorophenyl)-2-hydroxyethyl)pyrrolo [2,3-b]pyridine

HRID 1756057Notes

Reaction equation

HRID 1756057 reaction equation
Cl.[Cl:2][C:3]1[N:21]=[C:6]2[N:7]([CH2:11][C:12]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)=[O:13])[CH:8]=[CH:9][CH:10]=[C:5]2[C:4]=1[CH3:22]>CO>[Cl:2][C:3]1[N:21]=[C:6]2[N:7]([CH2:11][CH:12]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)[OH:13])[CH:8]=[CH:9][CH:10]=[C:5]2[C:4]=1[CH3:22]

Participants

3

Reactant 1

HCID 199167742-Chloro-3-methyl-7-(p-fluorophenacyl)pyrrolo [2,3-b]pyridine hydrochloride

Product 1

HCID 217438612-Chloro-3-methyl-7-(2-(p-fluorophenyl)-2-hydroxyethyl)pyrrolo [2,3-b]pyridineYield 99.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1,0 g (2,8 mmol) of 2-chloro-3-methyl-7-(p-fluorophenacyl)pyrrolo [2,3-b]pyridine hydrochloride in 50 ml methanol was treated with NaBH in the same manner as ex. 18 to give 0,85 g (99%) of the title compound as white solid.

Sources & evidence

ORD record
ord-76a8751ff4c1405c934144b7b22a52bd
Source dataset
uspto-grants-1995_08
Patent number
US05439917

Reaction notes

Loading…