2,3-Dimethyl-1H-pyrrolo[2,3-b]pyridine → 2,3-Dimethyl-7-(o-methylthiophenacyl)pyrrolo[2,3-b]pyridinehydrobromide

HRID 1756059Notes

Reaction equation

HRID 1756059 reaction equation
[CH3:1][C:2]1[NH:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]=1[CH3:11].[CH3:12][C:13]1[CH:22]=[CH:21][CH:20]=[CH:19][C:14]=1[C:15](=[S:18])[CH2:16][Br:17]>>[BrH:17].[CH3:1][C:2]1[N:10]=[C:5]2[N:6]([CH2:16][C:15]([C:14]3[CH:19]=[CH:20][CH:21]=[CH:22][C:13]=3[CH3:12])=[S:18])[CH:7]=[CH:8][CH:9]=[C:4]2[C:3]=1[CH3:11]

Participants

3

Reactant 2

HCID 125323872,3-Dimethyl-1H-pyrrolo[2,3-b]pyridineHCID 54146844o-Methylthiophenacyl bromide

Product 1

HCID 193925942,3-Dimethyl-7-(o-methylthiophenacyl)pyrrolo[2,3-b]pyridinehydrobromideYield 20.9%

Procedure

A solution of 0,2 g (1,4 mmol) 2,3-dimethylpyrrolo[2,3-b]pyridine and 0,34 g (1,4 mmol) o-methylthiophenacyl bromide was stirred at room temperature for 4 h. The precipitated product was filtred off and dried affording 0,11 g (20%) of the title compound.

Workup

  1. customdried

Sources & evidence

ORD record
ord-48e92292ffad4566b875e2bc85125334
Source dataset
uspto-grants-1995_08
Patent number
US05439917

Reaction notes

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