Bromomethyl 4-methoxyphenyl ketone → Hydrogen Bromide

HRID 1756062Notes

Reaction equation

HRID 1756062 reaction equation
[CH3:1][C:2]1[NH:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]=1[CH3:11].[CH3:12][O:13][C:14]1[CH:23]=[CH:22][C:17]([C:18](=[O:21])[CH2:19][Br:20])=[CH:16][CH:15]=1>>[CH3:1][C:2]1[N:10]=[C:5]2[N:6]([CH2:19][C:18]([C:17]3[CH:22]=[CH:23][C:14]([O:13][CH3:12])=[CH:15][CH:16]=3)=[O:21])[CH:7]=[CH:8][CH:9]=[C:4]2[C:3]=1[CH3:11].[BrH:20]

Participants

4

Reactant 2

HCID 4965Bromomethyl 4-methoxyphenyl ketoneHCID 125323872,3-Dimethyl-1H-pyrrolo[2,3-b]pyridine

Product 2

HCID 260Hydrogen BromideYield 336.1%HCID 675931242,3-Dimethyl-7-(p-metoxyphenacyl)pyrrolo[2,3-b]pyridine

Procedure

The title compound was prepared from 2,3-dimethylpyrrolo [2,3-b]pyridine (120 mg, 0.82 mmol) and p-methoxyphenacyl bromide (207 mg, 0.90 mmol) following the procedure in example 27 above furnishing 223 mg (73%) pure hydrobromide as a light yellow solid.

Sources & evidence

ORD record
ord-6517da498e51484dbd3048bc95a0ec34
Source dataset
uspto-grants-1995_08
Patent number
US05439917

Reaction notes

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