Hydrogen Bromide → 2,3-Dimethyl-7-(m-methoxyphenacyl)pyrrolo[2,3-b]pyridine

HRID 1756063Notes

Reaction equation

HRID 1756063 reaction equation
[CH3:1][C:2]1[NH:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]=1[CH3:11].[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:21]=[CH:22][CH:23]=1)[C:17](=[O:20])[CH2:18]Br.Br>>[CH3:1][C:2]1[N:10]=[C:5]2[N:6]([CH2:18][C:17]([C:16]3[CH:21]=[CH:22][CH:23]=[C:14]([O:13][CH3:12])[CH:15]=3)=[O:20])[CH:7]=[CH:8][CH:9]=[C:4]2[C:3]=1[CH3:11]

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 101294Bromomethyl 3-methoxyphenyl ketoneHCID 125323872,3-Dimethyl-1H-pyrrolo[2,3-b]pyridine

Product 1

HCID 217438452,3-Dimethyl-7-(m-methoxyphenacyl)pyrrolo[2,3-b]pyridine

Procedure

The title compound was prepared on a 0.9 mmol scale fr 2,3-dimethylpyrrolo[2,3-b]pyridine and m-methoxyphenacyl bromide in the same manner as described in example 27 giving 228 mg (70%) pure product as the hydrobromide.

Sources & evidence

ORD record
ord-6815399dacec4c0aa7cbc7e3bf8ccdb2
Source dataset
uspto-grants-1995_08
Patent number
US05439917

Reaction notes

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