Phenacyl bromide → 5-Bromo-2,3-dimethyl-7-phenacyl pyrrolo[2,3-b]pyridine

Participants

Reaction Steps

A solution of 5-bromo-2,3 -dimethyl-pyrrolo [2,3 -b]pyridine (prepared in a similar manner as 6-bromo-2,3-dimethyl-pyrrolo[2,3-b]pyridine (200 mg, 0.9 mmol) and phenacyl bromide (200 mg, 1.3 mmol) in 15 ml CH3CN was refluxed for 16 h. The mixture was allowed to cool and the precipitated product filtered off and washed with a small volume of diethyl ether affording 243 mg (72%) pure title compound as the hydrochloride.

Provenance & Evidence