反应详情

A mixture of 5-cyano-2,3-dimethyl-pyrrolo [2,3-b]pyridine (77 mg, 0.5 mmol ) and phenacyl chloride (650 mg, 4.2 mmol ) in 12 ml CH3CN was refluxed for 62 h. The mixture was basified with a saturated Na2CO3 solution and extracted with CH2Cl2. The organic layer was dried over MgSO4 and evaporated. The residue was chromatographed (silica, CH2Cl2 /diethyl ether;7/3) yielding 34 mg (26%) pure title compound.

1. temperaturewas refluxed for 62 h
2. extractionextracted with CH2Cl2
3. dry with materialThe organic layer was dried over MgSO4
4. customevaporated
5. customThe residue was chromatographed (silica, CH2Cl2 /diethyl ether;7/3)