Sodium Carbonate → 5-Cyano-2,3-dimethyl-7-phenacyl pyrrolo[2,3-b]pyridine

Participants

Reaction Steps

A mixture of 5-cyano-2,3-dimethyl-pyrrolo [2,3-b]pyridine (77 mg, 0.5 mmol ) and phenacyl chloride (650 mg, 4.2 mmol ) in 12 ml CH3CN was refluxed for 62 h. The mixture was basified with a saturated Na2CO3 solution and extracted with CH2Cl2. The organic layer was dried over MgSO4 and evaporated. The residue was chromatographed (silica, CH2Cl2 /diethyl ether;7/3) yielding 34 mg (26%) pure title compound.

Provenance & Evidence