Acetonitrile → HCID 19392596, compound

HRID 1756077Notes

Reaction equation

HRID 1756077 reaction equation
[C:1]([C:3]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][C:10]=2C)[NH:5][C:4]=1[CH3:13])#N.[CH2:14]([Cl:23])[C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:16].[C:24](#[N:26])C>>[ClH:23].[C:24]([CH2:1][C:3]1[C:11]2[C:6]([N:7]([CH2:14][C:15]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[O:16])[CH:8]=[CH:9][CH:10]=2)=[N:5][C:4]=1[CH3:13])#[N:26]

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 107572-ChloroacetophenoneHCID 70347403HCID 70347403, compound

Product 1

HCID 19392596HCID 19392596, compoundYield 58%

Procedure

A solution of 1.0 g (5.8 mmol) of 3-cyano-methyl-2-methyl pyrrolo[2,3-b]pyridine and 1.08 g (7.0 mmol) of phenacyl chloride in 50 ml acetonitrile was refluxed for 14 h. Working up in the same manner as described in example 17 gave 0,5 g 58% of the desired title compound.

Sources & evidence

ORD record
ord-1aeb9be6dee842fb9a9f4d7a338a8903
Source dataset
uspto-grants-1995_08
Patent number
US05439917

Reaction notes

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