2,6-Difluorophenacyl bromide → 2,3-Dimethyl-7(2.6-difluorophenacyl)pyrrolo [2,3-b]pyridine hydrobromide

HRID 1756080Notes

Reaction equation

HRID 1756080 reaction equation
[CH3:1][C:2]1[NH:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]=1[CH3:11].[F:12][C:13]1[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:14]=1[C:15](=[O:18])[CH2:16][Br:17]>C(#N)C>[BrH:17].[CH3:1][C:2]1[N:10]=[C:5]2[N:6]([CH2:16][C:15]([C:14]3[C:19]([F:23])=[CH:20][CH:21]=[CH:22][C:13]=3[F:12])=[O:18])[CH:7]=[CH:8][CH:9]=[C:4]2[C:3]=1[CH3:11]

Participants

4

Reactant 2

HCID 27782632,6-Difluorophenacyl bromideHCID 125323872,3-Dimethyl-1H-pyrrolo[2,3-b]pyridine

Product 1

HCID 217438422,3-Dimethyl-7(2.6-difluorophenacyl)pyrrolo [2,3-b]pyridine hydrobromideYield 55.9%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 100 mg (0.68 mmol) 2,3-dimethylpyrrolo[2,3-b]pyridine and 193 mg (0.82 mmol) 2,6-difluorophenacyl bromide in 2 ml acetonitrile were refluxed for 3 h. Working up in the same manner as described in example 17 gave 145 mg (54% ) of the desired product.

Sources & evidence

ORD record
ord-28109cfd58f047a0884c52d32b68a54a
Source dataset
uspto-grants-1995_08
Patent number
US05439917

Reaction notes

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