HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Difluorophenacyl bromide → 2,3-Dimethyl-7(2.6-difluorophenacyl)pyrrolo [2,3-b]pyridine hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Difluorophenacyl bromide | HCID 2778263 | — |
| Reactant | 2,3-Dimethyl-1H-pyrrolo[2,3-b]pyridine | HCID 12532387 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2,3-Dimethyl-7(2.6-difluorophenacyl)pyrrolo [2,3-b]pyridine hydrobromide | HCID 21743842 | 55.9% |
Reaction Steps
A solution of 100 mg (0.68 mmol) 2,3-dimethylpyrrolo[2,3-b]pyridine and 193 mg (0.82 mmol) 2,6-difluorophenacyl bromide in 2 ml acetonitrile were refluxed for 3 h. Working up in the same manner as described in example 17 gave 145 mg (54% ) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05439917 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-28109cfd58f047a0884c52d32b68a54a |
| Source note | uspto-grants-1995_08 |