反应详情

温度

5 °C

To a solution of 300 mg (2.36 mmol) of 2-methylpyrrolo[2,3-b]pyridine and 920 mg (11.3 mmol) of sodium thiocyanate in 5 ml acetic acid was added 450 mg (2.8 mmol) bromine in 1 ml acetic acid at 5° C. The reaction mixture was stirred for 30 min at 5° C. and thereafter for 16 h at room temperature. The solid was filtered off. To the filtrate was added 20 ml water. The precipitated product was filtered off and washed with water giving 160 mg (37%) of the title compound.

1. waitfor 16 h at room temperature
2. filtrationThe solid was filtered off
3. additionTo the filtrate was added 20 ml water
4. filtrationThe precipitated product was filtered off
5. washwashed with water giving 160 mg (37%) of the title compound