Bromine → 3-Thiocyano-2-methylpyrrolo[2,3-b]pyridine

Participants

Reaction Conditions

Reaction Steps

To a solution of 300 mg (2.36 mmol) of 2-methylpyrrolo[2,3-b]pyridine and 920 mg (11.3 mmol) of sodium thiocyanate in 5 ml acetic acid was added 450 mg (2.8 mmol) bromine in 1 ml acetic acid at 5° C. The reaction mixture was stirred for 30 min at 5° C. and thereafter for 16 h at room temperature. The solid was filtered off. To the filtrate was added 20 ml water. The precipitated product was filtered off and washed with water giving 160 mg (37%) of the title compound.

Provenance & Evidence