Carbon Dioxide → HCID 22477614, compound

HRID 1756107Notes

Reaction equation

HRID 1756107 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:16][C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[C:9]=2[CH3:17])=[CH:4][CH:3]=1.C([Li])CCC.[C:23](=[O:25])=[O:24]>C1COCC1>[C:23]([C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:16][C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[C:9]=2[CH3:17])=[CH:4][CH:3]=1)([OH:25])=[O:24]

Participants

5

Reactant 3

HCID 280Carbon DioxideHCID 22477214HCID 22477214, compoundHCID 178418339Butyllithium

Product 1

HCID 22477614HCID 22477614, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-(p-Bromophenyl)-3-methyl-pyrrolo-[2,3 -b]pyridine (1 g, 3.5 mmol) was dissolved in 200 ml dry THF, deaerated and cooled to -78° C. n-Butyllithium (5.19 ml, 8.4 mmol) was added dropwise and the mixture was allowed to reach room temperature CO2 (g) was bubbled through the solution for 10 min.

Workup

  1. additionwas added dropwise
  2. customto reach room temperature
  3. customwas bubbled through the solution for 10 min.

Sources & evidence

ORD record
ord-9ec4d62124464b65926d6843428abd6c
Source dataset
uspto-grants-1995_08
Patent number
US05439917

Reaction notes

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