Hydrochloric Acid → HCID 178420253, compound

HRID 1756123Notes

Reaction equation

HRID 1756123 reaction equation
Cl.C([N:9]1[C:13]([CH2:14][CH2:15][CH2:16][CH:17]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:12][N:11]=[CH:10]1)C1C=CC=CC=1.Cl.[H][H]>[Pd].C(O)C>[C:24]1([CH:17]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:16][CH2:15][CH2:14][C:13]2[N:9]=[CH:10][NH:11][CH:12]=2)[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14822311HCID 14822311, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 178420253HCID 178420253, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1-benzyl-5-(4,4-diphenylbutyl)-1H-imidazole hydrochloride (0,6 g) is hydrogenated in the mixture of 20 ml of 2N hydrochloric acid and 10 ml of ethanol at 80° C. Pd/C (10%) as catalyst. When the uptake of the hydrogen ceases, the reaction mixture is cooled, filtered and evaporated to dryness. Water is added and the mixture is made alkaline with sodium hydroxide. The product is then extracted to methylene chloride which is washed with water, dried with sodium sulphate and evaporated to dryness. The residue is the product as base and it is made to its hydrochloride in ethyl acetate using dry hydrochloric acid. Yield 0,2 g. M.p. 204°-206° C.

Workup

  1. filtrationfiltered
  2. customevaporated to dryness
  3. additionWater is added
  4. extractionThe product is then extracted to methylene chloride which
  5. washis washed with water
  6. dry with materialdried with sodium sulphate
  7. customevaporated to dryness

Sources & evidence

ORD record
ord-8615bf32d8b04e2d8d3fa16beafd1552
Source dataset
uspto-grants-1995_08
Patent number
US05439928

Reaction notes

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