Hydrochloric Acid → HCID 14822343, compound

HRID 1756126Notes

Reaction equation

HRID 1756126 reaction equation
[CH2:1]([N:8]1[C:12]([CH2:13][CH2:14][CH2:15][C:16](O)([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:11][N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>C(O)C>[CH2:1]([N:8]1[C:12]([CH2:13][CH2:14][CH:15]=[C:16]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[CH:11][N:10]=[CH:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14822341HCID 14822341, compound

Product 1

HCID 14822343HCID 14822343, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-benzyl-5-(4-hydroxy-4,4-diphenylbutyl)-1H-imidazole (1,3 g) is refluxed in 20 ml of ethanol containing 5% (w/w) hydrogen chloride for 1 hour. The solvent is evaporated and the HCl-salt of the product is precipitated with ethyl acetate. Yield 1,1 g, m.p. 161°-168° C.

Workup

  1. customThe solvent is evaporated
  2. customthe HCl-salt of the product is precipitated with ethyl acetate

Sources & evidence

ORD record
ord-0a8c66c7c47445c598bfe97c116f3582
Source dataset
uspto-grants-1995_08
Patent number
US05439928

Reaction notes

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