Hydrochloric Acid → HCID 178520568, compound

HRID 1756132Notes

Reaction equation

HRID 1756132 reaction equation
Cl.C([N:9]1[C:13]([CH:14]([OH:25])[CH2:15][CH2:16][CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:12][N:11]=[CH:10]1)C1C=CC=CC=1.Cl.[H][H]>[Pd].C(O)C>[OH:25][CH:14]([C:13]1[N:9]=[CH:10][NH:11][CH:12]=1)[CH2:15][CH2:16][CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 19916889HCID 19916889, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 178520568HCID 178520568, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1-benzyl-5-(1-hydroxy-5-phenylpentyl)-1H-imidazole hydrochloride (8,5 g), prepared in the Step a, is hydrogenated in the mixture of 100 ml of 2N hydrochloric acid and 10 ml of ethanol at 60° C. Pd/C (10%) as catalyst. When the uptake of the hydrogen ceases, the reaction mixture is cooled, filtered and evaporated to dryness. Water is added and the mixture is made alkaline with sodium hydroxide. The product is then extracted to methylene chloride which is washed with water, dried with sodium sulphate and evaporated to dryness. The residue is the product as base, and it is used as such in Step c.

Workup

  1. filtrationfiltered
  2. customevaporated to dryness
  3. additionWater is added
  4. extractionThe product is then extracted to methylene chloride which
  5. washis washed with water
  6. dry with materialdried with sodium sulphate
  7. customevaporated to dryness

Sources & evidence

ORD record
ord-71f1c29baf2d4cf6ac7dacc7daa17b3f
Source dataset
uspto-grants-1995_08
Patent number
US05439928

Reaction notes

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