Potassium bisulfate → HCID 14852374, compound

HRID 1756138Notes

Reaction equation

HRID 1756138 reaction equation
[CH2:1]([N:8]1[C:12]([C:13](O)([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:11][N:10]=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S([O-])(O)(=O)=O.[K+].C(N1C(C(C2C=CC=CC=2)=CCC2C=CC=CC=2)=CN=C1)C1C=CC=CC=1>C(OCC)C>[CH2:1]([N:8]1[C:12]([CH:13]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:14][CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[CH:11][N:10]=[CH:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 516920Potassium bisulfateHCID 14852372HCID 14852372, compoundHCID 53865229HCID 53865229, compound

Product 1

HCID 14852374HCID 14852374, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1-benzyl-5-(1-hydroxy-1,3-diphenylpropyl)-1H-imidazole is treated with anhydrous potassium hydrogen sulphate at 150° C. as described in Example 7 e). The double bond of the obtained intermediate, 1-benzyl-5-(1,3-diphenyl-1-propenyl)-1H-imidazole, is hydrogenated as described in Example 7 f). M.p. of the hydrochloride salt is 154°-174° C. (from diethylether).

Workup

  1. customis 154°-174° C.

Sources & evidence

ORD record
ord-c4a7248ebcb844de9d27470b9e37fdca
Source dataset
uspto-grants-1995_08
Patent number
US05439928

Reaction notes

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