Hydrochloric Acid → HCID 178420252, compound

HRID 1756139Notes

Reaction equation

HRID 1756139 reaction equation
C([N:8]1[C:12]([CH:13]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:11][N:10]=[CH:9]1)C1C=CC=CC=1.Cl>[Pd].C(O)C>[C:22]1([CH:13]([C:12]2[N:8]=[CH:9][NH:10][CH:11]=2)[CH2:14][CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 14852374HCID 14852374, compound

Product 1

HCID 178420252HCID 178420252, compoundYield 73%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1-benzyl-5-(1,3-diphenylpropyl)-1H-imidazole is hydrogenated in the mixture of 2N hydrochloric acid and ethanol at 60° C. 10% Pd/C as catalyst. The product is isolated as in Example 7 b) and is purified by flash chromatography methylene chloride-methanol (9,5:0,5) as eluent. Yield 73%.

Workup

  1. customThe product is isolated as in Example 7 b) and
  2. customis purified by flash chromatography methylene chloride-methanol (9,5:0,5) as eluent

Sources & evidence

ORD record
ord-214b4629d1ab434985c921b8899f8f96
Source dataset
uspto-grants-1995_08
Patent number
US05439928

Reaction notes

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