1-Bromo-4-fluorobenzene → HCID 19916876, compound

HRID 1756141Notes

Reaction equation

HRID 1756141 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][CH:3]=1.[CH2:9]([N:16]1[C:20]([CH:21]=[O:22])=[CH:19][N:18]=[CH:17]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH2:9]([N:16]1[C:20]([CH:21]([C:2]2[CH:7]=[CH:6][C:5]([F:8])=[CH:4][CH:3]=2)[OH:22])=[CH:19][N:18]=[CH:17]1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 99931-Bromo-4-fluorobenzeneHCID 27732391-Benzyl-1H-imidazole-5-carboxaldehyde

Product 1

HCID 19916876HCID 19916876, compoundYield 94%

Procedure

Grignard reaction of 4-bromofluorobenzene and 1-benzyl-5-imidazolecarbaldehyde is performed analogously to Example 7 a). The product is crystallized as hydrochloride salt from ethylacetate. Yield 94%.

Workup

  1. customThe product is crystallized as hydrochloride salt from ethylacetate

Sources & evidence

ORD record
ord-a23f21d49d3b44c1893b98b7470a4015
Source dataset
uspto-grants-1995_08
Patent number
US05439928

Reaction notes

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