Acetone → HCID 19917093, compound

HRID 1756158Notes

Reaction equation

HRID 1756158 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=2)[CH:9]=[O:10])=[CH:2]1.C(=O)([O-])[O-].[K+].[K+].[CH3:20][C:21]([CH3:23])=[O:22]>>[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:7]=[C:8]([CH:9]([OH:10])[CH2:20][C:21](=[O:22])[CH3:23])[CH:11]=[CH:12][CH:13]=2)=[CH:2]1

Participants

4

Reactant 3

HCID 180AcetoneHCID 11430Potassium CarbonateHCID 45475263-(Thiophen-3-yl)benzaldehyde

Product 1

HCID 19917093HCID 19917093, compound

Procedure

300 mg of 3-(3-thienyl)benzaldehyde was dissolved in 3 ml of acetone, and 441 mg of potassium carbonate was added. The mixture was sirred overnight at room temperature, and then the solvent was evaporated. The residue was worked up in a customary manner, and purified by medium-pressure liquid chromatography [hexane/ethyl acetate =3/1] to give 1-[3-(3-thienyl)-phenyl]-3-oxo-1-butanol as a colorless oil.

Workup

  1. customthe solvent was evaporated
  2. custompurified by medium-pressure liquid chromatography [hexane/ethyl acetate =3/1]

Sources & evidence

ORD record
ord-047c7c56f64944809b9582972db7b5c7
Source dataset
uspto-grants-1995_08
Patent number
US05439932

Reaction notes

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