Sodium Iodide → HCID 15341787, compound

HRID 1756184Notes

Reaction equation

HRID 1756184 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:21]=[CH:20][C:9]2[CH2:10][CH2:11][CH:12]([CH2:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])[O:13][C:8]=2[C:7]=1[CH2:22][CH2:23][CH3:24].[I-:25].[Na+]>C(C(C)=O)C>[I:25][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:21]=[CH:20][C:9]2[CH2:10][CH2:11][CH:12]([CH2:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])[O:13][C:8]=2[C:7]=1[CH2:22][CH2:23][CH3:24]

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 15341786HCID 15341786, compound

Product 1

HCID 15341787HCID 15341787, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

The compound of Example 2 (1.6 g, 4.521 mmol) was mixed with sodium iodide (6.8 g, 45.21 mmol) and methyl ethyl ketone (100 ml). The reaction mixture was stirred and refluxed overnight. The solvent was removed under vacuum and 100 ml of water was added to the residue. The solution was extracted three times with ethyl acetate. The extracts were combined, filtered, dried over magnesium sulfate and the solvent was removed under vacuum to give the product as a brown oil.

Workup

  1. temperaturerefluxed overnight
  2. customThe solvent was removed under vacuum and 100 ml of water
  3. additionwas added to the residue
  4. extractionThe solution was extracted three times with ethyl acetate
  5. filtrationfiltered
  6. dry with materialdried over magnesium sulfate
  7. customthe solvent was removed under vacuum

Sources & evidence

ORD record
ord-3d788fed100a46a08a0ae5fb1f102247
Source dataset
uspto-grants-1995_08
Patent number
US05439937

Reaction notes

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