Lithium Hydroxide → HCID 15341791, compound

HRID 1756188Notes

Reaction equation

HRID 1756188 reaction equation
[CH3:1][O:2][C:3]1[C:4]([CH2:37][CH:38]=[CH2:39])=[C:5]([CH:30]=[CH:31][C:32]=1[C:33]([NH:35][CH3:36])=[O:34])[O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:26]=[CH:25][C:14]2[CH2:15][CH2:16][CH:17]([CH2:19][CH2:20][C:21]([O:23]C)=[O:22])[O:18][C:13]=2[C:12]=1[CH2:27][CH2:28][CH3:29].[OH-].[Li+]>CO>[CH3:1][O:2][C:3]1[C:4]([CH2:37][CH:38]=[CH2:39])=[C:5]([CH:30]=[CH:31][C:32]=1[C:33]([NH:35][CH3:36])=[O:34])[O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:26]=[CH:25][C:14]2[CH2:15][CH2:16][CH:17]([CH2:19][CH2:20][C:21]([OH:23])=[O:22])[O:18][C:13]=2[C:12]=1[CH2:27][CH2:28][CH3:29]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 15341790HCID 15341790, compound

Product 1

HCID 15341791HCID 15341791, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound of Example 8 (250 mg, 0.4629 mmol) was dissolved in 2.0 ml of methanol and 694 μm of 1M lithium hydroxide was added. The reaction mixture was stirred at room temperature for about two days. The solvent was removed under vacuum and 20 ml of water was added. The aqueous residue was acidified with 10% hydrochloric acid. Filtration of the resultant suspension yielded the product as white solid.

Workup

  1. customThe solvent was removed under vacuum and 20 ml of water
  2. additionwas added
  3. filtrationFiltration of the resultant suspension

Sources & evidence

ORD record
ord-2653f55a2c604a1eb0c414664f225320
Source dataset
uspto-grants-1995_08
Patent number
US05439937

Reaction notes

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