Dimethyl Sulfate → HCID 15341841, compound

HRID 1756223Notes

Reaction equation

HRID 1756223 reaction equation
[CH:1]1([CH2:4][C:5]2[C:31]([OH:32])=[C:30]([C:33]([NH:35][CH3:36])=[O:34])[CH:29]=[CH:28][C:6]=2[O:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[C:13]([CH2:25][CH2:26][CH3:27])=[C:14]([CH:22]=[CH:23][CH:24]=2)[O:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:3][CH2:2]1.[CH3:37]OS(OC)(=O)=O.[OH-].[K+]>C1COCC1>[CH:1]1([CH2:4][C:5]2[C:31]([O:32][CH3:37])=[C:30]([C:33]([NH:35][CH3:36])=[O:34])[CH:29]=[CH:28][C:6]=2[O:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[C:13]([CH2:25][CH2:26][CH3:27])=[C:14]([CH:22]=[CH:23][CH:24]=2)[O:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 14797Potassium HydroxideHCID 15341840HCID 15341840, compound

Product 1

HCID 15341841HCID 15341841, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The compound of Example 63 is methylated (Me2SO4, KOH, THF) under the conditions described in Example 45. Chromatographic purification of the crude product on silica gel (Ethyl acetate/hexane (3:7) as eluant) affords the product.

Workup

  1. customChromatographic purification of the crude product on silica gel (Ethyl acetate/hexane (3:7) as eluant)
  2. customaffords the product

Sources & evidence

ORD record
ord-1d8eea3ccfbf4c149f38f4170bb8dd83
Source dataset
uspto-grants-1995_08
Patent number
US05439937

Reaction notes

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