Lithium Hydroxide → HCID 21479717, compound

HRID 1756227Notes

Reaction equation

HRID 1756227 reaction equation
[NH2:1][C:2]([C:4]1[CH:31]=[CH:30][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:26]=[CH:25][C:16]3[CH:17]=[CH:18][CH:19]([C:21]([O:23]C)=[O:22])[O:20][C:15]=3[C:14]=2[CH2:27][CH2:28][CH3:29])=[C:6]([CH2:32][CH:33]2[CH2:35][CH2:34]2)[C:5]=1[O:36][CH3:37])=[O:3].[OH-].[Li+]>C(OCC)(=O)C.CO.C(O)(=O)C>[NH2:1][C:2]([C:4]1[CH:31]=[CH:30][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:26]=[CH:25][C:16]3[CH2:17][CH2:18][CH:19]([C:21]([OH:23])=[O:22])[O:20][C:15]=3[C:14]=2[CH2:27][CH2:28][CH3:29])=[C:6]([CH2:32][CH:33]2[CH2:35][CH2:34]2)[C:5]=1[O:36][CH3:37])=[O:3]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 22399579HCID 22399579, compound

Product 1

HCID 21479717HCID 21479717, compound

Reagents, catalysts & solvents 1

HCID 22023684HCID 22023684, compoundSolvent

Procedure

The compound of Example 68 is saponified with lithium hydroxide using the conditions described in Example 26. Chromatography of the crude residue on silica gel using ethyl acetate/methanol/acetic acid as eluant (90:9.5:0.5) gives the product.

Workup

  1. customgives the product

Sources & evidence

ORD record
ord-466a7f5eac754743af94c21401a21ff8
Source dataset
uspto-grants-1995_08
Patent number
US05439937

Reaction notes

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