Lithium Hydroxide → HCID 15341844, compound

HRID 1756229Notes

Reaction equation

HRID 1756229 reaction equation
[NH2:1][C:2]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:14]([CH2:26][CH2:27][CH3:28])=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([O:20]CC)=[O:19])=[C:6]([CH2:31][CH:32]2[CH2:34][CH2:33]2)[C:5]=1[O:35][CH3:36])=[O:3].[OH-].[Li+]>C(OCC)(=O)C.CO.C(O)(=O)C>[NH2:1][C:2]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:14]([CH2:26][CH2:27][CH3:28])=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([OH:20])=[O:19])=[C:6]([CH2:31][CH:32]2[CH2:34][CH2:33]2)[C:5]=1[O:35][CH3:36])=[O:3]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 19026443HCID 19026443, compound

Product 1

HCID 15341844HCID 15341844, compound

Reagents, catalysts & solvents 1

HCID 22023684HCID 22023684, compoundSolvent

Procedure

The compound of Example 71 is saponified with lithium hydroxide using the conditions described in Example 26. Chromatography of the crude residue on silica gel using ethyl acetate/methanol/acetic acid as eluant (90:9.5:0.5) affords the product.

Workup

  1. customaffords the product

Sources & evidence

ORD record
ord-1cde39223fe946c48f2764784dc23fbb
Source dataset
uspto-grants-1995_08
Patent number
US05439937

Reaction notes

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