HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Paclitaxel
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Paclitaxel | HCID 36314 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Paclitaxel | HCID 36314 | — |
| Product | Acetone cardice | HCID 18522661 | — |
Reaction Steps
No taxol was found in the foreruns of experiments conducted with methylene chloride and acetone as cosolvents at 10 mole %. About half of the taxol (0.0242%) with a purification factor of 16 was recovered from the silica column in a methylene chloride cosolvent experiment (TAXC-36C). A SCF CO2 /acetone experiment (TAXC-37C) yielded less taxol (0.0147% with a purification factor of 15) from the silica column.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05440055 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-f40e78c14fa34bcbb43dc3159ae8bafe |
| Source note | uspto-grants-1995_08 |