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HRID1756285

反应详情

EQUATION

反应方程式

HRID 1756285 的结构方程式

REACTANTS

反应物

2
结构：ClCCl
HCID6344

Dichloromethane

CH2Cl2

结构：CC(=O)O[C@H]1C(=O)[C@@]2(C)[C@H]([C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C(C)=C1C3(C)C)[C@]1(OC(C)=O)CO[C@@H]1C[C@@H]2O
HCID36314

Paclitaxel

C47H51NO14

PRODUCTS

生成物

2
结构：CC(=O)O[C@H]1C(=O)[C@@]2(C)[C@H]([C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C(C)=C1C3(C)C)[C@]1(OC(C)=O)CO[C@@H]1C[C@@H]2O
HCID36314

Paclitaxel

C47H51NO14

结构：CC(C)=O.O=C=O
HCID18522661

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

No taxol was found in the foreruns of experiments conducted with methylene chloride and acetone as cosolvents at 10 mole %. About half of the taxol (0.0242%) with a purification factor of 16 was recovered from the silica column in a methylene chloride cosolvent experiment (TAXC-36C). A SCF CO2 /acetone experiment (TAXC-37C) yielded less taxol (0.0147% with a purification factor of 15) from the silica column.

WORKUP

后处理

  1. customAbout half of the taxol (0.0242%) with a purification factor of 16 was recovered from the silica column in a methylene chloride cosolvent experiment (TAXC-36C)