Hydrochloric Acid → HCID 131719082, compound

HRID 1756538Notes

Reaction equation

HRID 1756538 reaction equation
[Cl:1][C:2]1[CH:30]=[CH:29][C:5]2[O:6][C:7]3[CH:28]=[CH:27][CH:26]=[CH:25][C:8]=3[CH2:9][N:10]([C:11]([NH:13][CH2:14][C:15]([NH:17][CH2:18][C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[O:16])=[O:12])[C:4]=2[CH:3]=1.Cl.CO>O>[ClH:1].[Cl:1][C:2]1[CH:30]=[CH:29][C:5]2[O:6][C:7]3[CH:28]=[CH:27][CH:26]=[CH:25][C:8]=3[CH2:9][N:10]([C:11]([NH:13][CH2:14][C:15]([NH:17][CH2:18][C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)=[O:16])=[O:12])[C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 15288739HCID 15288739, compound

Product 1

HCID 131719082HCID 131719082, compoundYield 174.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To the title compound of Example 5 (0.10 g, 0.23 mmol) suspended in 30 mL of water was added 0.5 mL of 1N HCl . After stirring this suspension overnight at room temperature, 15 mL of MeOH were added giving a homogeneous solution. This reaction was diluted to 100 mL with water and lyophilized to provide 92 mg of the title compound as a white solid salt.

Workup

  1. customgiving a homogeneous solution

Sources & evidence

ORD record
ord-9d2711664e2c46f79d58f967d3b3fb9f
Source dataset
uspto-grants-1995_08
Patent number
US05441950

Reaction notes

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