2-Pyridinemethanamine → HCID 131719084, compound

HRID 1756553Notes

Reaction equation

HRID 1756553 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11](Cl)=[O:12])[C:4]=2[CH:3]=1.[NH2:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1>CCN(CC)CC>[ClH:1].[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11]([NH:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=3)=[O:12])[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 195092-PyridinemethanamineHCID 149759838-chlorodibenz[b,f][1,4]oxazepin-10(11H)carbonyl chloride

Product 1

HCID 131719084HCID 131719084, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

By the method described in Example 18, the title compound of Example 2 in CH2Cl 2 with molecular sieves #5A and Et3N was reacted with 2-(aminomethyl)pyridine to generate the free base of the title product. This material was converted to the title compound by the method described in Example 40.

Sources & evidence

ORD record
ord-dce50d55dd6848c5830488b7a8232bb8
Source dataset
uspto-grants-1995_08
Patent number
US05441950

Reaction notes

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