Isatin → HCID 478645, compound

HRID 1756575Notes

Reaction equation

HRID 1756575 reaction equation
Cl[C:2]1[CH:13]=[C:6]2[C:7]([O:9][C:10](=[O:12])[NH:11][C:5]2=[CH:4][CH:3]=1)=O.N1C2C(=CC=CC=2)C(=O)C1=O.[F:25][C:26]1[CH:27]=[C:28]2[C:32](=[CH:33][CH:34]=1)[NH:31][C:30](=O)C2=O>>[F:25][C:26]1[CH:34]=[C:33]2[C:32](=[CH:28][CH:27]=1)[N:31]=[C:30]1[C:7](=[O:9])[C:6]3[C:5]([N:11]1[C:10]2=[O:12])=[CH:4][CH:3]=[CH:2][CH:13]=3

Participants

4

Reactant 3

HCID 7054IsatinHCID 784805-Chloroisatoic anhydrideHCID 2365665-Fluoroisatin

Product 1

HCID 478645HCID 478645, compoundYield 57%

Procedure

Using the procedure in Example 12, and substituting 5-fluoroisatoic anhydride for 5-chloroisatoic anhydride and isatin for 5-fluoroisatin gave 650 mg (57%) of the title compound: mp 295° C. (dec); 1H NMR (DMSO-d6) δ 7.48-7.54 (m, 1H), 7.82-7.94 (m, 3H), 8.02-8.08 (m, 2H), 8.46-8.51 (m, 1H); MS (M+H)+ 267.1.

Sources & evidence

ORD record
ord-f69a03fb9c1049859268d8fecb52334d
Source dataset
uspto-grants-1995_08
Patent number
US05441955

Reaction notes

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