HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloroisatoic anhydride → 9-Chloroindolo[2,1-b]quinazoline-6,12-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloroisatoic anhydride | HCID 78480 | — |
| Reactant | 5-Fluoroisatin | HCID 236566 | — |
| Reactant | 6-Chloroindoline-2,3-dione | HCID 241331 | — |
| Product | 9-Chloroindolo[2,1-b]quinazoline-6,12-dione | HCID 336270 | 14% |
Reaction Steps
Using the procedure in Example 12 and substituting isatoic anhydride for 5-chloroisatoic anhydride and 6-chloroisatin for 5-fluoroisatin gave the title compound in 14% yield: mp 300.6°-303.1° C.; 1H NMR (300 MHz, DMSO-d6) δ 8.49 (d, 1H) 8.35 (d, 1H) 7.89 (d, 2H) 7.94 (d, 1H) 7.72-7.82 (m, 1H) 7.55-7.62 (m, 1H); MS (M+CH4CN)+ 324.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05441955 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-0515f78be70a4edaa896548edcd7e5b8 |
| Source note | uspto-grants-1995_08 |