2-Thiopheneboronic acid → 5-Trifluoromethyl-1H-benzimidazole

HRID 1756640Notes

Reaction equation

HRID 1756640 reaction equation
N[C:2]1[N:6](C2C=CC=C(I)C=2)[C:5]2[CH:14]=[CH:15][C:16]([C:18]([F:21])([F:20])[F:19])=[CH:17][C:4]=2[N:3]=1.S1C=CC=C1B(O)O>>[F:21][C:18]([F:19])([F:20])[C:16]1[CH:15]=[CH:14][C:5]2[N:6]=[CH:2][NH:3][C:4]=2[CH:17]=1

Participants

3

Reactant 2

HCID 27339602-Thiopheneboronic acidHCID 19390962HCID 19390962, compound

Product 1

HCID 3494445-Trifluoromethyl-1H-benzimidazole

Procedure

2-Amino-1-]3(2-thienyl)phenyl]-5-trifluoromethylbenzimidazole was prepared from 1-(2-amino-5-trifluoromethyl-1-benzimidazolyl)-3-iodobenzene and 2-thienylboronic acid according method B. mp 89°-91° C.

Sources & evidence

ORD record
ord-d2f8636b74dd4a27b67a0f273e949f68
Source dataset
uspto-grants-1995_08
Patent number
US05441969

Reaction notes

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