Pyrrolidine → HCID 15290020, compound

HRID 1756659Notes

Reaction equation

HRID 1756659 reaction equation
[C:1]([N:11]1[CH2:16][CH2:15][CH:14]([C:17](=[O:25])[C:18]2[CH:23]=[CH:22][C:21](F)=[CH:20][CH:19]=2)[CH2:13][CH2:12]1)([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].[NH:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1>>[C:1]([N:11]1[CH2:16][CH2:15][CH:14]([C:17](=[O:25])[C:18]2[CH:23]=[CH:22][C:21]([N:26]3[CH2:30][CH2:29][CH2:28][CH2:27]3)=[CH:20][CH:19]=2)[CH2:13][CH2:12]1)([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 19390934HCID 19390934, compound

Product 1

HCID 15290020HCID 15290020, compound

Conditions

Temperature
100 °C

Procedure

A mixture consisting of 4.1 g of 1-carbobenzoxy-4-(4-fluorobenzoyl)piperidine and 8 ml of pyrrolidine was stirred at 100° C. for 24 hours and the reaction mixtures was then worked up in the same manner as Example 2 to give 3.2 g of the title compound as oil.

Workup

  1. customthe reaction mixtures

Sources & evidence

ORD record
ord-fa315fab25c44747bef67175c20f96b3
Source dataset
uspto-grants-1995_08
Patent number
US05441967

Reaction notes

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