Piperidine → 1-Acetyl-3-(4-piperidinobenzoyl)piperidine

HRID 1756662Notes

Reaction equation

HRID 1756662 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH2:7][CH:6]([C:10](=[O:18])[C:11]2[CH:16]=[CH:15][C:14](F)=[CH:13][CH:12]=2)[CH2:5]1)(=[O:3])[CH3:2].[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[C:1]([N:4]1[CH2:9][CH2:8][CH2:7][CH:6]([C:10](=[O:18])[C:11]2[CH:16]=[CH:15][C:14]([N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)=[CH:13][CH:12]=2)[CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 8082PiperidineHCID 21939813HCID 21939813, compound

Product 1

HCID 193908341-Acetyl-3-(4-piperidinobenzoyl)piperidine

Conditions

Temperature
100 °C

Procedure

A mixture consisting of 3.73 g of 1-acetyl-3-(4-fluorobenzoyl)piperidine and 5 ml of piperidine was stirred at 100° C. for 24 hours and the reaction mixtures was then worked up in the same manner as Example 1. The residue was recrystallized from ethyl ether-n-hexane to give 3.2 g of colorless crystals melting at 116°-120° C.

Workup

  1. customthe reaction mixtures
  2. customThe residue was recrystallized from ethyl ether-n-hexane

Sources & evidence

ORD record
ord-9562f0076c7549e4a8aa0c9b72515eec
Source dataset
uspto-grants-1995_08
Patent number
US05441967

Reaction notes

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