Hydrochloric Acid → HCID 19390830, compound

HRID 1756666Notes

Reaction equation

HRID 1756666 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10](=O)[C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)=[CH:13][CH:12]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[ClH:24]>C(O)C>[ClH:24].[ClH:24].[C:1]([N:4]1[CH2:5][CH2:6][CH:7]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]3)=[CH:13][CH:12]=2)[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19390919HCID 19390919, compound

Product 1

HCID 19390830HCID 19390830, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 100 ml of ethanol was dissolved 4.8 g of the 1-acetyl-4-(4-piperazinobenzoyl)piperidine (Compound No. 2) prepared in Example 4, followed by addition of 3.5 ml of concentrated hydrochloric acid. The reaction mixture was worked up in the same manner as Examples 15 and 17 to give a solid, which was recrystallized from ethanol-ethyl acetate. The procedure gave 3.0 g of a hygroscopic colorless solid melting at 136°-137° C.

Workup

  1. customprepared in Example 4
  2. customto give a solid, which
  3. customwas recrystallized from ethanol-ethyl acetate

Sources & evidence

ORD record
ord-f45b818e538b48fd9c0eaaaadac06b70
Source dataset
uspto-grants-1995_08
Patent number
US05441967

Reaction notes

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