Dimethylamine → 1-Acetyl-4-(4-dimethylaminobenzoylmethyl)piperidine

HRID 1756671Notes

Reaction equation

HRID 1756671 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][C:11](=[O:19])[C:12]2[CH:17]=[CH:16][C:15](F)=[CH:14][CH:13]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[CH3:20][NH:21][CH3:22]>>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][C:11](=[O:19])[C:12]2[CH:17]=[CH:16][C:15]([N:21]([CH3:22])[CH3:20])=[CH:14][CH:13]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 100841181-Acetyl-4-(4-fluorobenzoylmethyl)piperidine

Product 1

HCID 193908471-Acetyl-4-(4-dimethylaminobenzoylmethyl)piperidine

Procedure

A mixture of 1.84 g of 1-acetyl-4-(4-fluorobenzoylmethyl)piperidine and 6 ml of a 50% aqueous solution of dimethylamine was stirred at room temperature for 3 days and the reaction mixture was worked up as in Example 1 to give 1.8 g of colorless crystals melting at 136° C.

Sources & evidence

ORD record
ord-551b2a18819446158dae6708cb7ef18e
Source dataset
uspto-grants-1995_08
Patent number
US05441967

Reaction notes

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