Hydrochloric Acid → HCID 19390792, compound

Participants

Reaction Steps

2-[5-Benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydropyrimidin-1-yl]-N-[3,3-difluoro-1-isopropyl-2-oxo-3-[N-(2-morpholinoethyl)carbamoyl]propyl]acetamide. Using a procedure similar to that described in Example 1, except omitting the 10% hydrochloric acid wash, the ketone was prepared; chromatography solvent: dichloromethane:methanol (gradient, 96:4, 95:5); TLC: Rf =0.41, dichloromethane:methanol (95:5); MS: m/z=687(M+1). Analysis for C33H37F3N6O7.0.95 H2O: Calculated: C, 56;32; H, 5.57; N, 11.94; Found: C, 56.28; H, 5.63; N, 11.90.

Provenance & Evidence