Hydrochloric Acid → HCID 19390792, compound

HRID 1756709Notes

Reaction equation

HRID 1756709 reaction equation
C(OC([NH:11][C:12]1[C:17](=[O:18])[N:16]([CH2:19][C:20]([NH:22][CH:23]([CH:40]([CH3:42])[CH3:41])[C:24](=[O:39])[C:25]([F:38])([F:37])[C:26](=[O:36])[NH:27][CH2:28][CH2:29][N:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)=[O:21])[C:15]([C:43]2[CH:48]=[CH:47][C:46]([F:49])=[CH:45][CH:44]=2)=[N:14][CH:13]=1)=O)C1C=CC=CC=1.Cl.ClCCl.CO>O.ClCCl.CO>[NH2:11][C:12]1[C:17](=[O:18])[N:16]([CH2:19][C:20]([NH:22][CH:23]([CH:40]([CH3:42])[CH3:41])[C:24](=[O:39])[C:25]([F:37])([F:38])[C:26](=[O:36])[NH:27][CH2:28][CH2:29][N:30]2[CH2:31][CH2:32][O:33][CH2:34][CH2:35]2)=[O:21])[C:15]([C:43]2[CH:44]=[CH:45][C:46]([F:49])=[CH:47][CH:48]=2)=[N:14][CH:13]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6344DichloromethaneHCID 19390795HCID 19390795, compound

Product 1

HCID 19390792HCID 19390792, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 21226129Dichloromethane methanolSolvent

Procedure

2-[5-Benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydropyrimidin-1-yl]-N-[3,3-difluoro-1-isopropyl-2-oxo-3-[N-(2-morpholinoethyl)carbamoyl]propyl]acetamide. Using a procedure similar to that described in Example 1, except omitting the 10% hydrochloric acid wash, the ketone was prepared; chromatography solvent: dichloromethane:methanol (gradient, 96:4, 95:5); TLC: Rf =0.41, dichloromethane:methanol (95:5); MS: m/z=687(M+1). Analysis for C33H37F3N6O7.0.95 H2O: Calculated: C, 56;32; H, 5.57; N, 11.94; Found: C, 56.28; H, 5.63; N, 11.90.

Workup

  1. washwash

Sources & evidence

ORD record
ord-803850216fc44bf8ae75fc7a782ca108
Source dataset
uspto-grants-1995_08
Patent number
US05441960

Reaction notes

Loading…