Pyridine → N-formyl-(S)-isoserine

HRID 1756726Notes

Reaction equation

HRID 1756726 reaction equation
[CH:1]([NH:3][CH2:4][C@@H:5]([C:7]([O:9]C=O)=[O:8])[OH:6])=[O:2].N1C=CC=CC=1>CO>[CH:1]([NH:3][CH2:4][C@@H:5]([C:7]([OH:9])=[O:8])[OH:6])=[O:2]

Participants

4

Reactant 2

HCID 1049PyridineHCID 86748890N,O-Diformyl,(S)-Isoserine

Product 1

HCID 22855355N-formyl-(S)-isoserine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A stock solution of N-formyl-(S)-isoserine was prepared by stirring 20 g (124.2 mmoles) of N,O-diformyl-(S)-isoserine in a mixture of methanol (85 ml) and pyridine (15 ml, 1.5 equiv.) at room temperature for 14-16 hrs. The completion of the reaction was judged by 1HNMR.

Sources & evidence

ORD record
ord-a4edcab0f56b4610817a2df7846508eb
Source dataset
uspto-grants-1995_08
Patent number
US05442047

Reaction notes

Loading…